LIVE 200 YEARS!!! IU1: Unveiling the Science Behind a Novel Anti-Aging Compound
An Assessment of IU1: A Novel Compound in the Pursuit of Healthy Aging Executive Summary The compound IU1 has recently garnered significant attention following research from Chung-Ang University, highlighting its potential in modulating cellular aging processes. IU1 is a small molecule identified as a reversible and specific inhibitor of human Ubiquitin Specific Peptidase 14 (USP14), an enzyme intrinsically linked to the proteasome, a critical component of the cell's protein degradation machinery. 1 Its initial discovery emerged from a high-throughput screening effort, demonstrating a notable selectivity for USP14 over other deubiquitinating enzymes (DUBs). 3 Recent investigations, particularly those led by Professor Seogang Hyun at Chung-Ang University, have explored IU1's capacity to address age-related impairments within the cellular protein quality control systems. 4 A pivotal finding from this research is that IU1's inhibition of USP14 concurrently enhances both pr...
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